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CYCLO DI-(DIPEPTIDE-17 HYDROXYPROLINE)

78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A cyclized synthetic dipeptide used in advanced anti-aging skincare formulations to support skin structure and firmness.

Cyclo Di-(Dipeptide-17 Hydroxyproline) is a cyclic dipeptide composed of two repeats of Dipeptide-17 Hydroxyproline, a hydroxyproline-containing dipeptide. Hydroxyproline is a key structural amino acid in collagen (approximately 13% of collagen's amino acid composition), making hydroxyproline-containing peptides biologically relevant in skin-matrix targeting cosmetics. The cyclization enhances stability compared to linear peptides. Under EU Regulation 1223/2009, synthetic peptides of this type are permitted cosmetic ingredients without specific restriction when used at cosmetic concentrations.

Skin benefits

  • May support collagen structure and skin firmness
  • Targeted toward skin matrix and anti-aging benefits
  • Enhanced stability from cyclization provides sustained activity in formulations

Known concerns

  • Potential for trace residual synthesis reagents requiring purity assessment
  • Generally well tolerated but eye contact should be avoided

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.