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Chelating Agent

CYCLO PEG-6

CAS 17455-13-9 Updated
50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

18-crown-6, a cyclic polyether that traps potassium ions. Useful as a chemical tool but not a benign humectant — animal data show real systemic toxicity, so cosmetic use should be very limited and well-justified.

Function

NOT REPORTED

Skin benefits

  • Chelates cations to stabilize sensitive actives
  • Can improve solubility of certain salts
  • Niche use in specialty formulations

Known concerns

  • Strong potassium ion binding linked to systemic toxicity in animal studies
  • Acute oral toxicity reported for crown ethers
  • Not a typical cosmetic-grade humectant; very limited cosmetic safety review

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.