Skin Conditioning
CYCLOHEXAPEPTIDE-75
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A cyclic six-amino-acid peptide used as a skin-conditioning agent. Cyclization improves stability; independent safety and efficacy data are limited.
Cyclohexapeptide-75 is a head-to-tail cyclized six-residue peptide developed for cosmetic skin-conditioning use. Cyclic peptides resist exopeptidase degradation, giving them a longer functional half-life on skin compared with linear peptides. As with most modern designer peptides it is dosed at parts-per-million levels in serums and creams. No independent CIR or SCCS review of this specific INCI is available; efficacy claims rely on supplier studies. Listed in EU CosIng. Conservative classification is yellow with low evidence.
Function
Skin benefits
- Improved on-skin stability via cyclization
- Trace-level skin conditioning
- Low sensitization potential
Known concerns
- Limited independent safety data
- No CIR/SCCS monograph
- Efficacy claims rely on supplier studies
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.