Skip to content

Cycloheximide

CAS 66-81-9
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cycloheximide is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Cycloheximide is a microbial toxin produced by Streptomyces griseus that inhibits eukaryotic protein synthesis. It is highly toxic by ingestion and dermal exposure, classified as a suspected reproductive toxicant and carcinogen. It has no authorized cosmetic use in the EU under Regulation 1223/2009 and its acute toxicity (LD50 ~2 mg/kg oral, mouse) makes any topical application entirely unacceptable.

Known concerns

  • Acute toxicity
  • Protein synthesis inhibitor
  • Suspected reproductive toxicant
  • No EU cosmetics authorization

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Check your shelf

Find Cycloheximide in your products.

Scan any cosmetic product with LuxSense to see if it contains Cycloheximide and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.