Skip to content

Cycloheximide

CAS 66-81-9
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Cycloheximide is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Cycloheximide is a microbial toxin produced by Streptomyces griseus that inhibits eukaryotic protein synthesis. It is highly toxic by ingestion and dermal exposure, classified as a suspected reproductive toxicant and carcinogen. It has no authorized cosmetic use in the EU under Regulation 1223/2009 and its acute toxicity (LD50 ~2 mg/kg oral, mouse) makes any topical application entirely unacceptable.

Known concerns

  • Acute toxicity
  • Protein synthesis inhibitor
  • Suspected reproductive toxicant
  • No EU cosmetics authorization

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Check your shelf

Find Cycloheximide in your products.

Scan any cosmetic product with LuxSense to see if it contains Cycloheximide and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.