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CYCLOTETRAPEPTIDE-24 AMINOCYCLOHEXANE CARBOXYLATE HCL

72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A four-amino-acid cyclic peptide with an aminocyclohexane carboxylate modification, designed to stimulate collagen and reduce expression lines.

Cyclotetrapeptides are a well-established class of cosmetic peptides. The cyclohexane ring constraint adds rigidity that may improve protease resistance compared to linear peptides. The HCl salt improves water solubility for formulation. Cyclic peptides below 1500 Da can penetrate the stratum corneum to some extent. Not listed in EU Annex II (banned) or III (restricted). The specific sequence (Cyclotetrapeptide-24) references the INCI designation system.

Skin benefits

  • Collagen stimulation for anti-wrinkle benefit
  • Anti-inflammatory properties reported for some cyclopeptides
  • Matrix metalloproteinase inhibition

Known concerns

  • Cyclohexane ring introduces hydrophobic character
  • HCl salt may cause minor irritation at high concentrations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.