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CYCLOVIROBUXINE

45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cyclovirobuxine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Cyclovirobuxine is a steroidal alkaloid isolated from Buxus species with documented pharmacological activity on cardiac sodium-potassium ATPase. It is used in traditional Chinese medicine but is not listed in EU CosIng for cosmetic applications. The lack of robust dermal safety and sensitization data, combined with its systemic cardiovascular activity, makes it unsuitable for unrestricted cosmetic use. EU cosmetics regulation requires safety data that do not appear to exist for this substance.

Known concerns

  • No EU CosIng listing
  • Known cardiovascular pharmacological activity
  • Insufficient dermal safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.