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DAIDZEIN

CAS 486-66-8
60

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Daidzein is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Daidzein (CAS 486-66-8) is a naturally occurring isoflavone phytoestrogen present in soybeans and other legumes. Under EU Regulation 1223/2009, it is listed in Annex III (entry III/374) with restriction conditions for cosmetic use. As a hormonal-active compound, it raises concerns about endocrine disruption, particularly with long-term use or application on damaged skin, limiting its overall safety score despite antioxidant benefits.

Skin benefits

  • Antioxidant protection against oxidative stress
  • Phytoestrogenic activity may support mature skin
  • Potential anti-aging benefits via collagen stimulation

Known concerns

  • EU Annex III restricted — III/374 applies
  • Phytoestrogenic activity raises endocrine disruption concerns
  • May enhance absorption through compromised skin barriers

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.