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Decamethonium bromide

CAS 541-22-0
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Decamethonium Bromide is a cosmetic ingredient. Exercise caution due to limited available safety data.

Decamethonium bromide is a depolarizing neuromuscular blocking agent (nmBA) used historically in surgical anesthesia. It acts by competitive blockade of nicotinic acetylcholine receptors at the motor endplate, causing muscle paralysis. The neuromuscular blocking action makes this substance completely inappropriate for cosmetic use. Any systemic absorption through skin could lead to serious adverse effects including respiratory paralysis.

Known concerns

  • Neuromuscular blocking agent
  • Muscle paralysis risk
  • No cosmetic authorization
  • Respiratory toxicity potential

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.