Skin Conditioning
DECAPEPTIDE-42
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A synthetic ten-amino-acid peptide used as a skin-conditioning signal ingredient. Safe at typical use levels, but efficacy leans on supplier data.
Decapeptide-42 is a 10-residue synthetic peptide supplied as an aqueous solution, usually delivering active peptide in the low ppm range. Short peptides as a class are non-irritating, non-sensitizing and readily biodegradable, and no GHS hazards are reported for this specific INCI. The ingredient has not been evaluated by CIR or the SCCS, and published efficacy studies — where they exist — are typically supplier-run rather than independently replicated. Stability in finished products depends on pH and preservation, as peptides can be cleaved by microbial proteases if contamination occurs.
Function
Skin benefits
- Skin-conditioning effect claimed by suppliers
- Very low-dose use limits exposure
- Benign profile typical of short peptides
Known concerns
- Thin independent evidence base
- No regulatory monograph
- Quality depends on manufacturer
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.