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Diazomethane

CAS 334-88-3
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Diazomethane is a cosmetic ingredient. Exercise caution due to limited available safety data.

Diazomethane (CH2N2) is a highly toxic and explosive yellow gas used primarily as a methylating agent in organic synthesis. EU CLP classification includes H350 (known carcinogen), H220 (extremely flammable gas), H315/H317 (irritation/sensitization), H318 (serious eye damage), H334 (respiratory sensitizer), and H370/H371 (organ toxicity). It is listed in EU Annex II of the Cosmetics Regulation, prohibiting its use in cosmetic products. The substance is also listed as a SVHC under REACH due to its carcinogenic and mutagenic properties.

Known concerns

  • Known carcinogen H350
  • Extremely flammable H220
  • Explosive gas
  • Respiratory sensitizer H334
  • Acute toxicity H370
  • Banned in EU cosmetics (Annex II)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.