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DICAFFEOYL LYSYL HEXAPEPTIDE-65

78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic hexapeptide conjugated with two caffeoyl groups, designed as an antioxidant and collagen-protective active ingredient.

Dicaffeoyl Lysyl Hexapeptide-65 combines the antioxidant power of caffeic acid with a short lysine-based peptide sequence. The dicaffeoyl modification enhances stability and skin penetration compared to unmodified caffeic acid. Peptides of this size are generally well-tolerated with low sensitisation potential. EU cosmetics allow synthetic peptides without specific restriction unless classified as CMR substances.

Skin benefits

  • Antioxidant protection against free radicals
  • Collagen degradation inhibition
  • Anti-inflammatory properties of caffeic acid moiety

Known concerns

  • Potential for trace caffeic acid oxidation
  • Generally low irritation profile for peptides

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.