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Difencloxazine (INN)

CAS 5617-26-5
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Difencloxazine (INN) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Difencloxazine is an investigational drug that was studied for analgesic and anxiolytic effects. It is not listed in the EU Cosmetics Regulation 1223/2009 Annexes and has no established safety profile for topical cosmetic use. The absence of cosmetic precedent, combined with its pharmacological activity profile as a CNS-acting drug, places it outside the scope of acceptable cosmetic ingredients. The INN designation indicates pharmaceutical, not cosmetic, development.

Known concerns

  • CNS-active pharmaceutical with no cosmetic safety data
  • No EU cosmetic regulatory approval
  • Experimental drug with unestablished safety profile
  • Pharmacological activity profile unsuitable for cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.