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Banned Substance

difenoxin

CAS 28782-42-5 Updated
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Difenoxin is a controlled opioid analgesic structurally related to pethidine, listed on EU Annex II as fully prohibited in cosmetic products. Pure regulatory-banned-substance reference, never a real cosmetic ingredient.

Skin benefits

  • No cosmetic skin benefit

Known concerns

  • EU Annex II prohibited
  • Controlled opioid status
  • CNS pharmacological activity
  • No safe cosmetic level

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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Check your shelf

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.