Skip to content

Banned Substance

difenoxin

CAS 28782-42-5
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Difenoxin is a controlled opioid analgesic structurally related to pethidine, listed on EU Annex II as fully prohibited in cosmetic products. Pure regulatory-banned-substance reference, never a real cosmetic ingredient.

Skin benefits

  • No cosmetic skin benefit

Known concerns

  • EU Annex II prohibited
  • Controlled opioid status
  • CNS pharmacological activity
  • No safe cosmetic level

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related banned substances

3
2-Methoxyethanol [1] and its acetate (2-Methoxyethyl acetate) [2]
Banned Substance
 3
Aniline, its salts and its halogenated and sulphonated derivatives
Banned Substance
 3
Apocynum cannabium L. and its preparations
Banned Substance
 3
DIETHYLENE GLYCOL
Banned Substance
 3
Daminozide
Banned Substance
 3
Dinoterb, its salts and esters
Banned Substance
 3
Dioxane
Banned Substance
 3
Diphtheria antitoxin
Banned Substance

Check your shelf

Find difenoxin in your products.

Scan any cosmetic product with LuxSense to see if it contains difenoxin and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.