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DIHYDROXYDIMETHOXYCHALCONE

CAS 227098-46-6
58

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dihydroxydimethoxychalcone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Dihydroxydimethoxychalcone is a polyhydroxylated chalcone structurally related to other skin-lightening chalcones like isochalcone. Its dimethoxy substitution pattern may affect its biological activity and safety profile. It is not listed in EU cosmetic restriction Annexes, but the absence of specific authorization combined with limited safety data places it in the moderate-concern category. Caution is warranted in leave-on formulations.

Skin benefits

  • Potential tyrosinase inhibition for skin lightening
  • Polyphenolic antioxidant structure

Known concerns

  • Limited toxicological and sensitization data
  • No EU CosIng authorization on record
  • Novel cosmetic use — insufficient market history

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.