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Synthetic Brightener

DIHYDROXYDIMETHOXYCHALCONE

CAS 227098-46-6
66

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic chalcone marketed as a pigmentation-reducing active. Lab data support tyrosinase inhibition, but chalcones as a class have measurable sensitisation potential and limited cosmetic regulatory review.

Skin benefits

  • Studied as tyrosinase inhibitor and skin-brightening agent
  • Antioxidant activity in vitro
  • Used at low percentages

Known concerns

  • Chalcone scaffold can sensitise the skin
  • Limited human clinical safety data
  • Photostability variable
  • No formal SCCS review

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.