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Dimethyl sulphate

CAS 77-78-1
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Dimethyl Sulphate is a cosmetic ingredient. Exercise caution due to limited available safety data.

Dimethyl sulphate is a classic chemical alkylating agent that methylates DNA and proteins, explaining its extreme toxicity profile (H350 carcinogen, H341 mutagen, H361 reproductive toxicant, H314 severe burns, H317/318/330 multiple routes of acute toxicity). It falls under EU Annex II prohibition as a CMR 1A substance. The compound has been used as a methylating agent in organic synthesis but has no cosmetic application.

Known concerns

  • EU Annex II CMR: prohibited in all cosmetic products
  • H350/H341/H361: confirmed carcinogen, mutagen, reprotoxicant
  • H314: severe chemical burns on skin contact
  • H317: skin sensitisation and H330: fatal by inhalation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.