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Skin Conditioning

DIOSGENIN DIPEPTIDE-33 HCL

60

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A dipeptide conjugated with diosgenin (a plant steroid) and supplied as the HCl salt. Used for skin conditioning at trace levels; data is limited.

Diosgenin Dipeptide-33 HCl is a synthetic conjugate of a dipeptide with diosgenin — a sapogenin (plant steroidal aglycone) traditionally extracted from wild yam (Dioscorea spp.) — supplied as the hydrochloride salt for cosmetic skin-conditioning use. Marketing typically references "phyto-steroid" or biomimetic activity. There is no CIR or SCCS opinion specific to this ingredient and no published GHS classification. Diosgenin itself is not biologically active as a hormone in humans without enzymatic conversion that does not occur in skin, but as a steroid scaffold it warrants more conservative scoring than a plain peptide. Use is at parts-per-million levels; intact peptide-steroid conjugates have negligible skin penetration. Independent efficacy data is sparse.

Function

SKIN CONDITIONING, SKIN PROTECTING

Skin benefits

  • Skin conditioning
  • Plant-steroid conjugate
  • Low irritation potential at trace levels

Known concerns

  • No regulatory monograph
  • Steroid scaffold warrants caution
  • Sparse independent data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.