Skin Conditioning
DIOSGENIN DIPEPTIDE-33 HCL
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A dipeptide conjugated with diosgenin (a plant steroid) and supplied as the HCl salt. Used for skin conditioning at trace levels; data is limited.
Diosgenin Dipeptide-33 HCl is a synthetic conjugate of a dipeptide with diosgenin — a sapogenin (plant steroidal aglycone) traditionally extracted from wild yam (Dioscorea spp.) — supplied as the hydrochloride salt for cosmetic skin-conditioning use. Marketing typically references "phyto-steroid" or biomimetic activity. There is no CIR or SCCS opinion specific to this ingredient and no published GHS classification. Diosgenin itself is not biologically active as a hormone in humans without enzymatic conversion that does not occur in skin, but as a steroid scaffold it warrants more conservative scoring than a plain peptide. Use is at parts-per-million levels; intact peptide-steroid conjugates have negligible skin penetration. Independent efficacy data is sparse.
Function
Skin benefits
- Skin conditioning
- Plant-steroid conjugate
- Low irritation potential at trace levels
Known concerns
- No regulatory monograph
- Steroid scaffold warrants caution
- Sparse independent data
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.