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Dioxethedrin (INN) and its salts

CAS 497-75-6
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dioxethedrin (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Dioxethedrin is a beta-adrenergic agonist with pharmacological activity similar to ephedrine and isoproterenol, used historically as a bronchodilator. The EU Cosmetics Regulation Annex III restricts its use at ≥0.1% in cosmetic products. This reflects concerns about sympathomimetic effects including tachycardia, hypertension, and CNS stimulation. Cosmetic use is inappropriate given its pharmaceutical mechanism and potential for systemic cardiovascular effects.

Known concerns

  • Sympathomimetic effects
  • Cardiovascular stimulation concerns
  • Restricted to ≤0.1% in EU cosmetics
  • CNS stimulation risk

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.