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DIOXOTHIAZETIDINYL DEMETHOXYRAPAMYCIN

25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Dioxothiazetidinyl Demethoxyrapamycin is a cosmetic ingredient. Exercise caution due to limited available safety data.

Dioxothiazetidinyl Demethoxyrapamycin is a semi-synthetic derivative of rapamycin (sirolimus), an immunosuppressant macrolide drug. It is not listed in EU Regulation 1223/2009 Annexes, indicating no specific prohibition, but its pharmacological activity as an mTOR inhibitor raises concern. Zero cosmetic product formulations are reported and no dermal safety data exists.

Known concerns

  • Immunosuppressant activity
  • No cosmetic safety data
  • Novel drug-derivative structure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.