Diphenhydramine citrate
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Diphenhydramine Citrate is a cosmetic ingredient. Exercise caution due to limited available safety data.
Diphenhydramine citrate is the citrate salt of diphenhydramine, a first-generation antihistamine. While diphenhydramine itself may be used in some topical cosmetic formulations for itch relief, its use is regulated in the EU. The compound carries potential for skin sensitization and is subject to concentration restrictions where permitted. Systemic absorption from topical application is a safety consideration.
Skin benefits
- Antipruritic (itch relief)
- Topical antihistamine activity
Known concerns
- Skin sensitization potential
- Systemic antihistamine effects from topical use
- Concentration-dependent regulation
- Not permitted in all cosmetic categories
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.