Other
DIPHENHYDRAMINE HCL
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A first-generation antihistamine drug (Benadryl). Topical use causes documented contact dermatitis and is regulated as a drug, not a cosmetic.
Diphenhydramine HCl (CAS 147-24-0) is a first-generation H1 antihistamine sold systemically as Benadryl and topically in some OTC anti-itch creams in the US. In the EU it is regulated as a medicinal product, not a cosmetic ingredient, and has no Cosmetics Regulation authorisation. Topical use is well documented to cause contact dermatitis and photoallergic dermatitis, paradoxically worsening the itch it is marketed to treat. Pediatric systemic toxicity has been reported when the drug was applied to large areas of broken skin. Cosmetic presence would either be illegal (EU) or cross-over into OTC drug territory (US) and is outside cosmetic safety frameworks.
Skin benefits
- OTC topical anti-itch (drug, not cosmetic)
Known concerns
- Regulated as drug, not cosmetic
- Topical contact and photoallergic dermatitis
- Pediatric systemic toxicity on large-area application
- Not authorised in EU cosmetics
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.