Diphenhydramine hydrochloride
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Diphenhydramine Hydrochloride is a cosmetic ingredient. Exercise caution due to limited available safety data.
Diphenhydramine hydrochloride is a first-generation antihistamine used in some topical pharmaceutical preparations. Under EU cosmetic regulation, its use is restricted and it is primarily regulated as a medicinal substance by national competent authorities.
Known concerns
- Topical antihistamine - restricted in EU cosmetics
- Potential for skin sensitization with prolonged use
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.