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Diphenylpyraline (INN) and its salts

CAS 147-20-6
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Diphenylpyraline (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Diphenylpyraline is a first-generation antihistamine (H1-receptor antagonist) with anticholinergic properties. Under EU Cosmetics Regulation Annex III, it is restricted to concentrations below 0.1% when present as a constituent of other substances or in mixtures. Its systemic pharmacological effects make unsupervised cosmetic use a regulatory concern.

Known concerns

  • Restricted in EU cosmetics (Annex III, <0.1%)
  • Systemic antihistamine activity
  • Anticholinergic effects
  • May cause drowsiness

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.