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Fragrance

DODECANENITRILE

CAS 2437-25-4
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A long-chain aliphatic nitrile used in perfumery. Aliphatic nitriles can release cyanide metabolically — conservative orange placement.

Dodecanenitrile (CAS 2437-25-4) is a saturated C12 aliphatic nitrile used as a specialty fragrance ingredient for waxy, fatty-metallic notes. Aliphatic nitriles can undergo metabolic hydrolysis to release cyanide, a class-level toxicology concern documented for several aliphatic nitriles of various chain lengths. Long-chain examples generally have lower acute toxicity than short-chain nitriles (like acetonitrile or butyronitrile) because of slower absorption and metabolism, but the class hazard is why nitriles as fragrance materials are used sparingly and subject to RIFM/IFRA scrutiny. Public SCCS/CIR data for this specific compound is limited.

Function

PERFUMING

Skin benefits

  • Waxy fatty note
  • Formulation stability

Known concerns

  • Aliphatic nitrile metabolic cyanide release class concern
  • Limited cosmetic-specific data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.