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Skin Conditioning

ENDONUCLEASE V

70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A bacterial DNA-repair enzyme used in trace amounts in advanced post-sun and anti-aging formulas. Generally safe at cosmetic levels but recombinant origin requires careful endotoxin and purity control.

Function

SKIN PROTECTING

Skin benefits

  • May support DNA-repair processes in UV-stressed skin
  • Targeted enzymatic activity (cleaves at deaminated bases)
  • Used at trace concentrations in advanced photo-protective formulas

Known concerns

  • Recombinant bacterial enzyme — potential residual endotoxin if not pharma-grade
  • Stability and activity in topical formulas often poor without specialized delivery
  • Limited public safety dossier specific to topical use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.