Ergocalciferol (INN) and Cholecalciferol (vitamins D2 and D3)
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A cosmetic ingredient. Exercise caution due to limited available safety data.
Ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) are fat-soluble vitamins essential for calcium homeostasis. In cosmetic products, they may be used at low concentrations for skin health claims. However, the narrow therapeutic window of vitamin D means excessive topical application could contribute to hypervitaminosis D, a serious condition. Cosmetic formulations must carefully control D vitamin concentrations.
Skin benefits
- Supports skin barrier function
- May enhance calcium signalling in epidermal cells
- Antioxidant properties in skin
Known concerns
- Narrow safety window for vitamin D
- Risk of hypervitaminosis D with excessive use
- Well-tolerated at regulated cosmetic concentrations
- Systemic absorption possible through skin
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.