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ESCULETIN

CAS 305-01-1
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

ESCULETIN is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

Esculetin is a natural phenolic coumarin found in several plant species. Under EU cosmetic regulation, coumarin is listed in Annex III as a fragrance allergen requiring declaration when present above 0.001% in leave-on products. The compound exhibits photosensitizing properties, increasing skin susceptibility to UV damage, which limits its use in sun-exposed formulations. CAS 305-01-1.

Skin benefits

  • Antioxidant properties

Known concerns

  • Photosensitization risk
  • Coumarin fragrance allergen (EU Annex III)
  • Limited toxicity data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.