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fenoxazoline

CAS 4846-91-7
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Fenoxazoline is a cosmetic ingredient. Exercise caution due to limited available safety data.

Fenoxazoline is an imidazoline-derivative alpha-adrenergic agonist with vasoconstrictive properties similar to naphazoline and xylometazoline. Used in topical nasal decongestants, it carries risks of rebound congestion and cardiovascular effects with systemic absorption. It is a pharmaceutical substance not approved for cosmetic use and falls under general REACH restrictions for substances in mixtures at ≥0.1%.

Known concerns

  • Alpha-adrenergic vasoconstrictor activity
  • Rebound congestion risk
  • Cardiovascular effects
  • Not approved for cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.