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Banned Chemotherapy Agent

Fluorouracil (INN)

CAS 51-21-8
1

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Fluorouracil is a prescription cytotoxic chemotherapy drug used medically for actinic keratosis and cancers. It is prohibited in EU cosmetics under Annex II with no legitimate skincare use whatsoever.

Skin benefits

  • Effective prescription chemotherapy and actinic keratosis treatment under medical supervision
  • Annex II listing provides strong consumer protection against illicit cosmetic misuse

Known concerns

  • EU Annex II prohibited substance in cosmetics
  • Cytotoxic antimetabolite chemotherapy agent
  • Severe local reactions: inflammation, erosion, ulceration
  • Teratogenic and genotoxic, contraindicated in pregnancy

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.