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Fluorouracil (INN)

CAS 51-21-8
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Fluorouracil (inn) is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Fluorouracil is a cytotoxic antimetabolite that interferes with DNA and RNA synthesis, used exclusively as a pharmaceutical agent in cancer chemotherapy and topical dermatology for precancerous lesions. Its mechanism of action makes it completely inappropriate and prohibited in cosmetic products. In the EU, cytotoxic pharmaceuticals are banned from cosmetic formulations under Regulation (EC) No 1223/2009 Annex II.

Known concerns

  • cytotoxic antimetabolite
  • EU Annex II banned
  • not for cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.