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Pharmaceutical corticosteroid (prohibited)

fluprednisolone

CAS 53-34-9
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A fluorinated corticosteroid prohibited from cosmetic products in the EU and most jurisdictions. Strictly a prescription drug with serious adverse effects when used outside medical supervision.

Skin benefits

  • Prescription corticosteroid with anti-inflammatory action under medical use
  • Used in dermatology under physician supervision for specific conditions

Known concerns

  • Prohibited in cosmetics under EU Regulation 1223/2009 Annex II (corticosteroids)
  • Chronic topical use causes skin atrophy, telangiectasia, and rebound dermatitis
  • Systemic absorption can suppress the hypothalamic-pituitary-adrenal axis
  • Increases risk of skin infections and steroid-induced acne
  • Illegal in over-the-counter cosmetics worldwide

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.