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gepefrine

CAS 18840-47-6
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Gepefrine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Gepefrine is a phenylethanolamine sympathomimetic agent that acts as a vasoconstrictor and is structurally related to compounds with stimulant properties. While it has been used in some topical pharmaceutical preparations, its sympathomimetic activity raises concerns about systemic absorption, cardiovascular effects (including blood pressure elevation), and potential interactions with other pharmaceuticals. The compound is not listed in EU Annexes I–VI of Regulation 1223/2009 as a permitted cosmetic ingredient, suggesting it is not recognized as suitable for cosmetic use. Limited long-term safety data and its pharmacological activity make it a substance of concern for skin care applications.

Skin benefits

  • Vasoconstrictor — may reduce puffiness in topical pharmaceutical formulations

Known concerns

  • Sympathomimetic cardiovascular activity
  • Vasoconstriction effects
  • Limited cosmetic safety data
  • Potential systemic absorption concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.