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GINSENOSIDE RG2

CAS 52286-74-5
78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A protopanaxadiol-type ginsenoside from Panax ginseng with anti-inflammatory and anti-apoptotic effects in skin cells.

Ginsenoside Rg2 (protopanaxadiol saponin) differs from Rg1 in sugar attachment and is slightly more hydrophobic. Like Rg1, it is non-genotoxic and has a long history of oral and topical use in traditional medicine. The H302 classification confirms low acute oral toxicity. EU cosmetics regulation does not specifically restrict ginsenosides; they are treated as botanical-derived cosmetic ingredients.

Skin benefits

  • Anti-apoptotic protection of dermal fibroblasts
  • Collagen synthesis stimulation
  • Inhibition of UV-induced skin damage

Known concerns

  • H302: low acute oral toxicity
  • Potential for glucocorticoid-mediated hormonal effects
  • Botanical allergenicity possible

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.