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Phospholipid derivative

GLYCEROPHOSPHOCHOLINE

CAS 28319-77-9
76

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A choline-rich phospholipid building block related to lecithin. It is used as a gentle barrier-supporting and hydrating ingredient in skincare, with a generally favorable tolerance profile.

Skin benefits

  • Choline-containing phospholipid building block, similar to lecithin
  • Supports skin barrier and acts as a humectant
  • Compatible with sensitive and dry skin formulations
  • Used at a wide concentration range in creams, gels, and lotions

Known concerns

  • Specific cosmetic safety review for GPC is limited compared with lecithin
  • Quality and purity depend on the source and manufacturing process
  • Best evidence comes from systemic and aesthetic uses rather than topical cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.