HARPAGOSIDE
Conditioning Agent
Good
CAS Number: 19210-12-9
About HARPAGOSIDE
The key active from devil's claw root — a potent natural anti-inflammatory used to soothe irritated skin. Generally safe topically, though harmful if swallowed.
Detailed Analysis
Harpagoside (C₂₄H₃₀O₁₁, CAS 19210-12-9, CID 5281542) is an iridoid glycoside and the principal bioactive compound in Harpagophytum procumbens (devil's claw). It exhibits significant anti-inflammatory activity by inhibiting COX-2 and NF-κB pathways. GHS classification includes H302 (harmful if swallowed, 95.2%), with a 'Warning' signal word — this is an oral toxicity concern, not a topical one. In cosmetic applications it's used topically at low concentrations for its anti-inflammatory and skin-soothing properties. Extensive research supports its efficacy in reducing inflammation.
What It Does
Skin Benefits
- ✓ Potent anti-inflammatory — inhibits COX-2 and NF-κB
- ✓ Soothes irritated and inflamed skin
- ✓ Skin conditioning properties
- ✓ Well-researched bioactive compound
Known Concerns
- ⚠ Harmful if swallowed (H302) — oral toxicity concern
- ⚠ Limited topical-specific safety data
- ⚠ May interact with blood-thinning medications if absorbed systemically
Safety Score
Good
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.