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HESPERIDINASE

CAS 37213-47-1
78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A plant-derived enzyme that hydrolyzes flavonoids, used in cosmetics for its ability to break down citrus-derived compounds.

Hesperidinase (CAS 37213-47-1) is an enzyme preparation derived from fungal sources (typically Aspergillus species) that hydrolyzes hesperidin and related citrus flavonoids. Enzymatic modification of flavonoids can enhance their bioavailability in skin. The EU Cosmetics Regulation requires enzyme preparations to meet microbial purity standards and specifies activity limits. Hesperidinase itself is not a known sensitizer and is generally well-tolerated on skin. Fungal-derived enzymes require careful sourcing to ensure absence of mycotoxins and proper purification. Used in citrus-based skincare lines and flavonoid-enriched formulations.

Skin benefits

  • Enzymatic modification of citrus flavonoids
  • May enhance bioavailability of skin-benefiting compounds
  • Supports breakdown of naringin in skin

Known concerns

  • Fungal source requires purity verification
  • May degrade citrus flavonoids in formulations over time

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.