Skin Conditioning
HEXACARBOXYMETHYL DIPEPTIDE-12
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A heavily carboxymethylated short peptide used as a skin-conditioning ingredient. Mild profile, but efficacy evidence is mostly supplier-generated.
Hexacarboxymethyl dipeptide-12 is a dipeptide (two amino acids) chemically modified with six carboxymethyl groups to boost water solubility and metal-chelating-like behavior. In cosmetics it is positioned as a skin-conditioning and firming peptide. Short modified peptides as a class tend to be low-irritant and are used at low percentages, but there is no CIR or SCCS review, and publicly available efficacy data largely comes from supplier marketing rather than independent trials. Safety profile is reassuring by analogy but not by direct assessment.
Function
Skin benefits
- Skin-conditioning peptide signal
- Water-soluble for serum use
Known concerns
- No independent safety/efficacy monograph
- Proprietary supplier evidence only
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.