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Hexaethyl tetraphosphate

CAS 757-58-4
10

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Hexaethyl Tetraphosphate is a cosmetic ingredient. Exercise caution due to limited available safety data.

Hexaethyl tetraphosphate is an organophosphate ester historically used as a plasticiser and flame retardant. The tetraphosphate structure indicates potent cholinesterase inhibition, analogous to parathion-type insecticides. REACH Annex XVII restrictions prohibit use above 0.1% in mixtures, effectively eliminating cosmetic use. The EU cosmetics regulation independently prohibits substances subject to SVHC identification.

Known concerns

  • SVHC under REACH: prohibited in cosmetics above 0.1%
  • Cholinesterase inhibition: neurotoxicity concern
  • No safe use level established for cosmetic application

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.