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HINOKITIOL

CAS 499-44-5
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Hinokitiol is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Hinokitiol (CAS 499-44-5) is a tropolone-type compound found in cypress and cedar wood oils with broad-spectrum antibacterial, antifungal, and anti-inflammatory activity. It is listed in EU Annex III of Regulation 1223/2009 with restriction conditions for its use in cosmetic products. While it has potential skin benefit applications, concerns around sensitisation and restricted use levels reduce its overall safety score.

Skin benefits

  • Broad-spectrum antimicrobial activity
  • Anti-inflammatory properties
  • Potential for acne-prone skin applications
  • Antioxidant activity

Known concerns

  • EU Annex III restricted — concentration limits apply
  • Potential skin sensitiser at higher concentrations
  • Limited long-term sensitisation data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.