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Banned pharmaceutical alkaloid

Hydrastinine hydrochloride

CAS 4884-68-8
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Hydrastinine hydrochloride is an old pharmaceutical alkaloid derived from goldenseal, used historically as a haemostatic. It is a drug substance, not a cosmetic ingredient, and is banned from skincare in the EU.

Skin benefits

  • Historical pharmaceutical use as a haemostatic agent
  • No legitimate cosmetic application

Known concerns

  • Alkaloid drug substance, not a cosmetic ingredient
  • Cardiovascular and uterine pharmacological activity
  • Banned from cosmetic use under EU Annex II
  • Toxicity poorly characterised by modern standards

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.