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Fragrance Schiff base

HYDROXYCITRONELLAL-INDOLE SCHIFF BASE

CAS 68527-79-7
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Hydroxycitronellal-indole Schiff base is a floral fragrance Schiff base derived from the known sensitizer hydroxycitronellal. It is functional in perfumery but carries skin-allergy risk and IFRA limits.

Skin benefits

  • Floral-aromatic fragrance material used in perfumes and personal care
  • Provides long-lasting lily of the valley and animalic notes

Known concerns

  • Built from hydroxycitronellal, an established contact allergen restricted by IFRA
  • Schiff base may dissociate and release the parent sensitizer in product or on skin
  • EU includes hydroxycitronellal in the list of 26 declarable fragrance allergens
  • Use levels in leave-on products are tightly limited by IFRA Standards

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.