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pH Adjuster

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

CAS 7365-45-9 Updated
76

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

HEPES — a biological buffer also used in cosmetics for mild surface exfoliation and pH control. Generally well tolerated at low %; raw material can irritate eyes.

Function

BUFFERING

Skin benefits

  • pH buffering at physiological range
  • Mild keratolytic effect at low %
  • Used in exfoliating leave-ons
  • Stable over wide pH

Known concerns

  • Mild keratolytic activity may sting sensitive skin
  • Limited long-term cosmetic safety data
  • Eye irritant on raw material

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

PC

PubChem

U.S. NIH compound data, GHS hazard codes and toxicity literature.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.