Fragrance
INDOLE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
The iconic trace component of jasmine absolute — white-floral at dilution, fecal at concentration. FEMA GRAS; used sparingly in perfumery.
Indole (CAS 120-72-9) is a bicyclic heteroaromatic naturally present in jasmine, orange blossom, neroli, and gardenia essential oils, and is also produced by gut microbial tryptophan metabolism. In perfumery it is a signature trace ingredient of white floral and narcotic-floral bases — intense and malodorous neat, but at dilution it gives the characteristic heady jasmine effect. FEMA GRAS for flavor use. At high doses some genotoxicity signals appear in the literature, but at cosmetic trace use levels (often <0.1%) these are not considered practically relevant. RIFM/IFRA cover the material. Upper-yellow (70) reflects practical skin compatibility balanced against cautious high-dose toxicology.
Function
Skin benefits
- Signature jasmine/white floral note
- FEMA GRAS
- Natural floral constituent
Known concerns
- Malodorous neat
- Higher-dose genotoxicity signals
- Normal fragrance allergen load
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related fragrances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.