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Aromatic ketone intermediate

ISATIN

CAS 91-56-5
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An indole-derived aromatic ketone used mainly as a synthesis intermediate and dye precursor. Cosmetic use is uncommon and limited safety data leave open questions about sensitisation.

Function

HAIR DYEING

Skin benefits

  • Used historically as a dye intermediate giving red-orange tones
  • Serves as a chemical precursor in indigo and indole chemistry
  • Studied for antimicrobial activity in cosmetic research

Known concerns

  • Limited cosmetic safety data and no SCCS approval as a finished cosmetic ingredient
  • Aromatic ketone with potential skin sensitisation flag
  • Genotoxicity signals in some in vitro assays
  • Possible photoreactivity on UV exposure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.