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ISOBUTYLAMIDO THIAZOLYL RESORCINOL

CAS 1428450-95-6
75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Also known as Thiamidol — a highly effective skin-brightening ingredient that reduces dark spots by blocking melanin production, with fewer side effects than hydroquinone.

Isobutylamido Thiazolyl Resorcinol (CAS 1428450-95-6), marketed as Thiamidol, is a potent tyrosinase inhibitor developed by Beiersdorf for treating hyperpigmentation. It inhibits human tyrosinase (the rate-limiting enzyme in melanin synthesis) with high specificity. Clinical studies demonstrate efficacy comparable to or exceeding hydroquinone for melasma and post-inflammatory hyperpigmentation, with a more favorable side-effect profile. GHS codes H317 (skin sensitizer) and H411 (aquatic toxicity) apply to the raw material. Approved as the first new whitening cosmetic ingredient under China's CSAR in 2024.

Function

ANTIOXIDANTBLEACHINGSKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Potent tyrosinase inhibition for treating hyperpigmentation
  • Effective against melasma and dark spots
  • Fewer side effects than hydroquinone
  • No paradoxical hyperpigmentation observed
  • Suitable for long-term use

Known concerns

  • May cause allergic skin reaction (H317 skin sensitizer)
  • Toxic to aquatic life with long-lasting effects (H411)
  • Relatively new ingredient — long-term data still accumulating
  • Patch testing recommended before use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.