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Botanical antimicrobial

ISOLEPTOSPERMONE

CAS 5009-05-2
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A naturally occurring beta-triketone found in manuka oil. It contributes to the antibacterial and skin-clarifying performance of manuka extracts used in acne and blemish-targeted cosmetics.

Skin benefits

  • Beta-triketone constituent of manuka oil with antimicrobial activity
  • Contributes to anti-acne and antibacterial action of manuka oil
  • Active at low concentrations within manuka-oil formulations
  • Patch testing of manuka oil reported satisfactory tolerance

Known concerns

  • Triketones can be skin sensitisers in susceptible individuals
  • No dedicated CIR or SCCS opinion on isoleptospermone in isolation
  • Manuka-oil components show genus-level allergen overlap with Myrtaceae
  • Use level matters; high neat concentrations may irritate

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.