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ISONIACIN

CAS 55-22-1
80

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Isoniacin is a cosmetic ingredient. Exercise caution due to limited available safety data.

Isoniacin (pyridine-4-carboxylic acid or isonicotinic acid) is a vitamin B3 derivative closely related to niacin. It carries H315/H319/H335 (irritation) classifications at standard conditions. Unlike niacin, it does not cause flushing at typical cosmetic concentrations. The compound supports skin barrier function, reduces transepidermal water loss, and has brightening properties. No EU cosmetic restrictions apply to this vitamin derivative.

Skin benefits

  • Skin barrier strengthening
  • Antioxidant support
  • Brightening properties
  • Supports ceramide synthesis

Known concerns

  • Mild skin irritation potential at high concentrations
  • Eye irritation (H319) concern

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.