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ketobemidone

CAS 469-79-4
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Ketobemidone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Ketobemidone (4-(3-hydroxyphenyl)-1-methyl-4-piperidinyl ethyl ketone) is a potent opioid agonist with analgesic efficacy significantly exceeding morphine. It is controlled under the 1961 UN Single Convention on Narcotic Drugs and appears on EU Annex II as a prohibited cosmetic ingredient. The compound carries a well-documented risk of severe adverse effects including respiratory depression, and its high lipid solubility raises concerns about dermal absorption and systemic opioid effects.

Known concerns

  • EU Annex II banned — potent controlled opioid
  • Respiratory depression and CNS depression risk
  • High abuse potential and physical dependence

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.