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KUSHENOLS/KURARINONE

53

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Potent prenylated flavonoids from Sophora flavescens root with strong anti-inflammatory and antimicrobial activity, but notable sensitisation and toxicity concerns.

Kushenols and kurarinone are prenylated flavonoids isolated from the roots of Sophora flavescens (Kushen), a key herb in traditional Chinese medicine (TCM). Kushenols A-L and kurarinone arelavonoids with a geranyl side chain conferring strong biological activity. They are potent NADPH oxidase inhibitors, suppressing reactive oxygen species production in neutrophils. Kurarinone is also a direct 5-lipoxygenase inhibitor. The prenylated structure responsible for their activity is also associated with photosensitisation and contact allergy. Repeated topical application has been associated with contact dermatitis in experimental models.

Skin benefits

  • Potent anti-inflammatory
  • Antimicrobial
  • Antioxidant

Known concerns

  • Known photosensitiser — increases UV-induced skin damage risk
  • Allergic contact dermatitis reported
  • Prenylated flavonoids are sensitising agents
  • EU Annex III restricted compounds possible

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.