LACCASE
Other
Good
CAS Number: 80498-15-3
About LACCASE
An oxidative enzyme produced by engineered Aspergillus oryzae, used in cosmetics primarily for its ability to cross-link phenolic compounds, providing controlled delivery and stability.
Detailed Analysis
Laccase (EC 1.10.3.2) is an enzyme derived from Myceliophthora thermophila produced in Aspergillus oryzae expression systems. Enzyme-based cosmetic ingredients are assessed under EU regulation for potential allergenicity and irritancy. Laccase itself is not listed in EU Annex restrictions. However, the production organism Aspergillus oryzae is a known source of fungal allergens, and residual host protein must be controlled. SCCS has not issued a specific opinion on laccase; it is considered safe at current use levels with appropriate purity standards.
Skin Benefits
- ✓ Acts as an oxidoreductase in topical formulations
- ✓ May enhance stability of active compounds
- ✓ Skin-conditioning through fermentation-derived metabolites
Known Concerns
- ⚠ Residual fungal host proteins may pose allergen risk
- ⚠ Requires documentation of production strain and purity
Safety Score
Good
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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