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LAPACHOL

35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Lapachol is a cosmetic ingredient. Exercise caution due to limited available safety data.

Lapachol is a naphthoquinone compound extracted from the inner bark of the lapacho tree (Tabebuia impetiginosa). It has been studied for antimicrobial and anti-inflammatory properties but has raised concerns regarding genotoxicity and photosensitization potential. Not explicitly listed in EU Cosmetics Regulation 1223/2009 annexes, but its photosensitization risk (increased UV sensitivity) and genotoxicity concerns warrant careful safety assessment before use in leave-on cosmetic products.

Skin benefits

  • Anti-inflammatory and antimicrobial properties
  • Potential wound-healing benefits
  • Antioxidant activity

Known concerns

  • Photosensitization risk: may increase UV-induced skin damage
  • Genotoxicity concerns reported in literature
  • Should be used with caution in sun-exposed formulations
  • Limited human safety data available

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.