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Levonordefrin [USAN]

CAS 829-74-3
6

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Levonordefrin [USAN] is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Levonordefrin (CAS 829-74-3) is an adrenergic vasoconstrictor used in dental and medical anesthesia. It has alpha-adrenergic agonist activity causing significant vasoconstriction. This pharmaceutical agent is explicitly prohibited from cosmetic products under EU Regulation 1223/2009 Annex II. Its pharmacological activity and potential for systemic absorption make it incompatible with cosmetic use.

Known concerns

  • Systemic vasoconstrictor with alpha-adrenergic activity
  • Prohibited pharmaceutical agent in cosmetics
  • EU Annex II banned substance
  • Not a cosmetic-grade material

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.